Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell - download pdf or read online

By Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, József Jászai (auth.), Denis Corbeil (eds.)

ISBN-10: 1461458935

ISBN-13: 9781461458937

ISBN-10: 1461458943

ISBN-13: 9781461458944

​​​​​​​Prominin-1 or differently often called CD133 is a glycoprotein that's found in people and mice. because the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a wide curiosity particularly, as a stem mobile marker, that gave upward thrust to an ever growing to be physique of courses and extra lately its expression in melanoma stem cells. Controversies as to its position as a melanoma stem and its detection in numerous versions, in addition to its use as a prognostic marker have emerged. but, past its use as a stem telephone and melanoma stem phone marker, prominin-1/CD133 monitors precise organic beneficial properties and looks of significance in different methods like for instance in retinal biogenesis. certainly, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is linked to numerous crucial procedures like phone polarity, uneven mobile department and membrane home improvement. we suggest to study present wisdom approximately this interesting molecule and current pertinent details to figure out the organic position of prominins and verify their significance in drugs and melanoma study. the first viewers for this publication is geared in the direction of scientists and researchers with curiosity in melanoma stem cells, stem cells, phone biology, neurobiology, and regenerative medicine.

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Additional info for Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

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Huttner HB, Corbeil D, Thirmeyer C, Coras R, Köhrmann M et al (2012) Increased membrane shedding–indicated by an elevation of CD133-enriched membrane particles – into the CSF in partial epilepsy. Epilepsy Res 99:101–106 63. Kania G, Corbeil D, Fuchs J, Tarasov KV, Blyszczuk P et al (2005) The somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells 23:791–804 64. Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomson JA (2001) Hematopoietic colony-forming cells derived from human embryonic stem cells.

Zhou F, Cui C, Ge Y, Chen H, Li Q et al (2010) Alpha2,3-Sialylation regulates the stability of stem cell marker CD133. J Biochem 148:273–280 42. Sgambato A, Puglisi MA, Errico F, Rafanelli F, Boninsegna A et al (2010) Post-translational modulation of CD133 expression during sodium butyrate-induced differentiation of HT29 human colon cancer cells: implications for its detection. J Cell Physiol 224:234–241 43. Mak AB, Blakely KM, Williams RA, Penttilä PA, Shukalyuk AI et al (2011) CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope.

Tirino V, Desiderio V, d’Aquino R, De Francesco F, Pirozzi G et al (2008) Detection and characterization of CD133+ cancer stem cells in human solid tumours. PLoS One 3:e3469 137. Yin S, Li J, Hu C, Chen X, Yao M et al (2007) CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer 120:1444–1450 138. Suetsugu A, Nagaki M, Aoki H, Motohashi T, Kunisada T et al (2006) Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells.

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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology by Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, József Jászai (auth.), Denis Corbeil (eds.)

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