By Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, József Jászai (auth.), Denis Corbeil (eds.)
Prominin-1 or differently often called CD133 is a glycoprotein that's found in people and mice. because the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a wide curiosity particularly, as a stem mobile marker, that gave upward thrust to an ever growing to be physique of courses and extra lately its expression in melanoma stem cells. Controversies as to its position as a melanoma stem and its detection in numerous versions, in addition to its use as a prognostic marker have emerged. but, past its use as a stem telephone and melanoma stem phone marker, prominin-1/CD133 monitors precise organic beneficial properties and looks of significance in different methods like for instance in retinal biogenesis. certainly, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is linked to numerous crucial procedures like phone polarity, uneven mobile department and membrane home improvement. we suggest to study present wisdom approximately this interesting molecule and current pertinent details to figure out the organic position of prominins and verify their significance in drugs and melanoma study. the first viewers for this publication is geared in the direction of scientists and researchers with curiosity in melanoma stem cells, stem cells, phone biology, neurobiology, and regenerative medicine.
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Additional info for Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology
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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology by Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, József Jászai (auth.), Denis Corbeil (eds.)