Jean-Michel Foidart, Ruth J. Muschel's Proteases and Their Inhibitors in Cancer Metastasis PDF

By Jean-Michel Foidart, Ruth J. Muschel

ISBN-10: 1402009232

ISBN-13: 9781402009235

ISBN-10: 1402020082

ISBN-13: 9781402020087

Lately, serine proteases and matrix metalloproteinases (MMPs) have received significant cognizance in tumor biology. for many of those proteases, their expression is a competent indication of ongoing tissue home improvement. This e-book offers a complete overview of the mechanisms of motion of proteases and their inhibitors in tumor biology. the 1st half offers the reader with a selective evaluation of the molecular biology of serine proteases, MMPs and their physiological inhibitors. crucial proteases and their physiological in addition to artificial inhibitors are evaluated within the so much proper versions of experimental and human melanoma. The medical elements also are taken under consideration. This quantity bargains an replace in this difficult element of melanoma remedy, its curiosity bias, and attainable scientific implication.

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It appears therefore that several mitogenic signals can be switched on by uPA and that different parts of the uPA molecule may be involved depending upon cell type and mechanisms [for a review, see (Schmitt et al, 2000)]. The uPAR is a true chemotactic molecule whose activity lies within the protease-sensitive region linking domains 1 and 2 of uPAR, which can be cleaved by uPA. Synthetic peptides spanning this epitope promote chemotaxis and activate P56/p59 hck tyrosine kinase. Thus uPAR can be transformed through cleavage by uPA or other protease(s) into a chemokine acting on the same, or neighboring cells (Blasi, 1997; Fazioli et al, 1997).

They are indeed targeting key gene products of tumour associated host cells such as inflammatory cells, endothelial cells, fibroblasts . . These cells are indeed responsible for the bulk production of proteases in many tumors. Since tumor invasion, growth and angiogenesis result from a coordinated interaction between tumoral cells and host cells, it is anticipated that the selective inhibition of host cells activation in tumor might block cancer progression. Protease inhibitors of the MMPs and of the plasminogen activation system and antiangiogenic agents might therefore be excellent candidates to cancer treatments targeting normal host cells.

Both have been hypothesized to play major roles in tumor progression, tumor cell invasion and angiogenesis. -M. J. ), Proteases and Their Inhibitors in Cancer Metastasis, 39–52.  2002 Kluwer Academic Publishers. Printed in the Netherlands. activity to digest the underlying basement membrane and hence gain access to the mesenchymal tissue as part of the invasive phenotype distinguishing benign from malignant cancers. The matrix metalloproteinase family has many members and is subdivided into four families.

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Proteases and Their Inhibitors in Cancer Metastasis by Jean-Michel Foidart, Ruth J. Muschel


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