Download e-book for kindle: Protein Folding, Misfolding and Aggregation by Munoz V. (ed.)

By Munoz V. (ed.)

ISBN-10: 0854042571

ISBN-13: 9780854042579

This distinct e-book covers the entire sleek ways and the numerous advances skilled within the box over the last 10 years. there's a lot emphasis on computational equipment and reviews of protein aggregation that have rather flourished within the final decade. It contains chapters within the parts that experience witnessed significant advancements and written by means of best specialists together with: machine simulations of folding, quickly folding, unmarried molecule spectroscopy, protein layout, aggregation stories (both computational and experimental). Readers will receive a distinct viewpoint of the issues confronted within the biophysical research of protein conformational habit in aqueous answer and the way those difficulties are being solved with a multidisciplinary method that mixes idea, test and desktop simulations.

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Additional resources for Protein Folding, Misfolding and Aggregation

Sample text

1 Helix Interior Different approaches have been used in order to determine the helical propensity or preference of individual amino acids. Scheraga and co-workers used a host–guest strategy (see above) to derive values for the helical preference of various amino acid residues. The host–guest system uses long random copolymers of a water soluble, non-ionic guest (poly[N5-(3-hydroxypropyl)-Lglutamine] (PHPG) or poly[N5-(4-hydroxybutyl)-L-glutamine] (PHBG)), together with a low (10–50%) content of the guest residue.

D. Poland and H. A. Scheraga, Theory of Helix-Coil Transitions in Biopolymers, Academic Press, New York and London, 1970. 85. H. Qian and J. A. Schellman, J. Phys. , 1992, 96, 3987. 86. A. J. Doig, Biophys. , 2002, 101–102, 281. 87. B. H. Zimm and J. K. Bragg, J. Chem. , 1959, 31, 526. 88. S. Lifson and A. Roig, J. Chem. , 1961, 34, 1963. 89. J. K. Sun and A. J. Doig, Prot. , 1998, 7, 2374. 90. F. B. Sheinerman and C. L. Brooks, J. Am. Chem. , 1995, 117, 10098. 91. P. J. Flory, Statistical Mechanics of Chain Molecules, Wiley, New York, 1969.

More details on helical structure, stability, and design are covered in Chapter 1 by Doig and in the references therein. a-Helix formation represents a classic prototype of conformational transition in polymers. Usually such processes are fast, ranging from nanoseconds to milliseconds, thus making their measurements difficult. The common experimental approach to measure the dynamics of such fast events is to induce a shift in the equilibrium by a rapid perturbation and to monitor the ensuing relaxation to the new equilibrium.

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Protein Folding, Misfolding and Aggregation by Munoz V. (ed.)


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