Rare Tumors In Children and Adolescents - download pdf or read online

By Dominik Schneider, Ines B. Brecht, Thomas A. Olson, Andrea Ferrari

ISBN-10: 3642041965

ISBN-13: 9783642041969

This is the 1st ebook to be dedicated solely to infrequent tumors in little ones and children, and its target is to supply up to date info on their analysis and medical administration. the hole part addresses normal matters together with epidemiology, hazard factors/etiology, biology and genetics, early detection, and screening. It additionally discusses ideas to aid within the administration of infrequent tumors, resembling overseas networking and net systems. within the moment part, particular malignancies are defined, with useful tips on diagnostic workup, multimodal treatment, follow-up, and adversarial results. dialogue of differential prognosis encompasses either common and infrequent tumor kinds, which may still let the clinician to take infrequent entities into consideration in the course of the diagnostic evaluation. every one bankruptcy is going directly to offer targeted healing instructions for particular infrequent tumors. The authors are a multidisciplinary team of experts who've devoted themselves to this workforce of tumors.

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Additional resources for Rare Tumors In Children and Adolescents

Example text

2006). The discovery of the diagnostic inaccuracy in a relatively straightforward case, such as rhabdomyosarcoma, only further elucidates the diagnostic and classification issues with difficulty and rare tumors. A separate example illustrating the failures of conventional diagnostic tools pertains to a newborn who was clinically diagnosed with stage IV S-neuroblastoma. The histology showed an undifferentiated neoplasm composed of large epitheliod cells, which was not supportive of the clinical diagnosis (Fig.

In addition to inhibition of protein expression, the data suggest that the product may induce inhibition of cell growth in MYCN-expressing medulloblastoma cell lines. Data corroborating the plausibility were seen in neuroblastoma. With all these data, the regulatory authorities were able to accept the medical plausibility for orphan designation, keeping in mind that the rationale for the development was justified and that the product deserved further development with the help of incentives from the orphan regulation.

By blinding, by central review, by meticulous trial conduct, and by inclusion of a broad set of supportive endpoints. With a view to minimizing the number of participants in a clinical trial, it may be possible to assume a large treatment effect, if this is the minimum clinically relevant, realistic effect of a novel medicine worth detecting in a rare tumor with unmet needs. Alternatively, a trial could be discontinued on the basis of futility analyses if the desirable treatment effect cannot be achieved.

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Rare Tumors In Children and Adolescents by Dominik Schneider, Ines B. Brecht, Thomas A. Olson, Andrea Ferrari


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