By A. P. Adams, J. N. Cashman, R. M. Grounds (Editors)
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Extra resources for Recent Advances in Anaesthesia and Intensive Care 022 (Recent Advances)
To the physician the complexities of stereochemistry and the intricacies of the associated terminology are of little interest. A not unreasonable attitude as they could expect the pharmaceutical industry and the regulatory agencies to provide them with the most appropriate material irrespective of stereochemical considerations. However, it is important that physicians are aware of the nature of the material they are prescribing, mixture or single chemical entity, particularly with the advent of the Chiral Switch9 (see below) and the possibility that both racemate and single stereoisomer products of some agents either are, or will be, available at the same time.
Whether or not COX-2 inhibitors can provide some level of protection in these forms of cancer remains to be established. 148,149 There is strong evidence from receptor knockout studies in the mouse that PGE2 and PGF2␣, and their respective E prostaglandin (EP) and F prostaglandin (FP) receptors mediated events during reproduction. 151 FP receptor knockout mice have a normal early pregnancy and oestrous cycle. Interestingly, PGF2␣ induces luteolysis in wild type animals, so again there seems to be mechanisms to compensate for the loss of this pathway.
FASEB J 1998; 12: 1063–1073. 143. Williams CS, Smalley W, DuBois RN. Aspirin use and potential mechanisms for colorectal cancer prevention. J Clin Invest 1997; 100: 1325–1329. 144. Masferrer J. Approach to angiogenesis inhibition based on cyclooxygenase-2. Cancer J 2001; 7 (Suppl 3): S144–S150. 145. Zimmermann KC, Sarbia M, Weber AA, Borchard F, Gabbert HE, Schror K. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res 1999; 59: 198–204. qxd 9/11/02 12:56 PM The COX Enzyme System Page 29 29 146.
Recent Advances in Anaesthesia and Intensive Care 022 (Recent Advances) by A. P. Adams, J. N. Cashman, R. M. Grounds (Editors)