By Gail S. Prins Ph.D., Wen-Yang Hu Ph.D. (auth.), Scott D. Cramer (eds.)
Recent facts demonstrates that ordinary prostate tissue includes stem cells. there's additionally gathering facts that prostate melanoma features a inhabitants of cells with stem cell-like features often called melanoma stem cells, or tumor beginning cells. either the conventional prostate stem cellphone and melanoma stem telephone populations have very important implications for the new release, healing concentrating on, and prevention of prostate melanoma. the aim of this e-book is to discover the function of stem cells in prostate melanoma, that is changing into an more and more sizzling development in melanoma learn.
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Additional info for Stem Cells and Prostate Cancer
2003; Shackleton et al. 2006; Lim et al. 2009; Rock et al. 2009). Isolated cell populations can be tested using clonogenic in vitro assays that provide a quantitative measure of their proliferative and self-renewal activity. The two most commonly used assays are the colony-forming assay, measuring clonogenic and proliferative potential, and the sphere-forming assay, measuring both clonogenicity and self-renewal in vitro in a quantitative fashion (Fig. 1). S. N. Witte 24 In vitro clonogenic assays Colony-formation Keratin 8 Dissociate prostate to single cells Keratin 5 Plate on Matrigel or irradiated feeder cells Sphere-formation Suspend in Matrigel Optional: fractionate total cells into subsets to enrich for stem/progenitors Dissociated sphere cells can serially generate new spheres Fig.
2, lineage tracing in the adult mouse prostate demonstrated that basal cells give rise to basal cells and luminal cells give rise to luminal cells in a unipotent manner (Choi et al. 2012). Using a dissociated cell tissueregeneration assay, numerous groups have identified cells capable of multi-lineage differentiation capacity (Burger et al. 2005, 2009; Xin et al. 2005, 2007; Lawson et al. 2007, 2010; Goldstein et al. 2008, 2010; Leong et al. 2008; Wang et al. 2009). Do these assays (tissue recombination using embryonic mesenchyme vs.
1970; Clarkson 1969; Killmann et al. 1963), and the work (together with others’) suggested that a fraction of proliferative leukemic cells can replenish the bulk leukemic blasts and result in leukemia in vivo. However, identification of a true CSC population was not successful until the 1990s, when Dick and colleagues provided solid evidence that most subtypes of acute myeloid leukemia (AML) are organized as a hierarchy and only the CD34+CD38- leukemic stem cells have the ability to serially reconstitute AML in immunodeficient mice (Lapidot et al.
Stem Cells and Prostate Cancer by Gail S. Prins Ph.D., Wen-Yang Hu Ph.D. (auth.), Scott D. Cramer (eds.)