By Michael Khan, Stella Pelengaris
This entire textual content offers a close evaluate of the molecular mechanisms underpinning the advance of melanoma and its therapy. Written via a world panel of researchers, experts and practitioners within the box, the textual content discusses all points of melanoma biology from the motives, improvement and prognosis via to the therapy of melanoma.
* Written via a global panel of researchers, experts and practitioners within the box
* Covers either conventional components of research and parts of controversy and rising value, highlighting destiny instructions for study
* beneficial properties up to date insurance of modern experiences and discoveries, in addition to a superior grounding within the key innovations within the box
* every one bankruptcy contains key issues, bankruptcy summaries, textual content bins, and topical references for additional comprehension and evaluate
* Supported by means of a committed web site at www.blackwellpublishing.com/pelengaris
* a great textual content for upper-level classes within the biology of melanoma, for clinical scholars and certified practitioners getting ready for larger assessments, and for researchers and lecturers within the box
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Extra resources for The Molecular Biology of Cancer
Et al. (2005). Crucial role of p53-dependent cellular senescence in suppression of Pten-deﬁcient tumorigenesis. Nature, 436(7051): 725–30. , et al. (2005). BRAFE600-associated senescencelike cell cycle arrest of human naevi. Nature, 436(7051): 720–4. , and Evan, G. (2004). Intrinsic tumor suppression. Nature, 432(7015): 307–15. I. (2002). Suppression of MYC-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell, 109(3): 321–34.
Apoptosis and necrosis are not the only forms of cell death described; others include anoikis, endoplasmic reticulum stress. More recently another potential balance against inappropriate replication has been described, namely irreversible exit from the cell cycle (senescence – see Fig. 9). This is described in detail in Chapter 9. Cells are continually receiving and integrating a variety of both positive and negative growth signals. One intriguing result of much research over the last 20 years has been the appreciation that cells seem only too willing to commit suicide.
Many such changes may actively support tumor cell invasion, survival, and growth and this is particularly important in epithelial carcinogenesis (Chapter 12). Interactions between cancer cells and their environment are thus key determinants of tumor progression. In recent years, a considerable interest has developed in “immune privilege” (Chapter 13). Foreign antigens that enter immunologically privileged sites, of which the eye, brain, and testis are examples, can survive for an extended period of time, whereas the same antigens would normally be swiftly eliminated elsewhere.
The Molecular Biology of Cancer by Michael Khan, Stella Pelengaris