By Michihiro Mieda PhD, Takeshi Sakurai MD, PhD (auth.), Seiji Nishino MD, PhD, Takeshi Sakurai MD, PhD (eds.)
Impairment of orexin/hypocretin signaling reasons narcolepsy-cataplexy in animals and people. so much human narcolepsy-cataplexy circumstances are linked to orexin/hypocretin ligand deficiency, which are detected clinically utilizing cerebrospinal orexin/hypocretin measures and should result in destiny remedies with orexin/hypocretin alternative remedy. within the Orexin/Hypocretin procedure: body structure and Pathophysiology, major researchers and clinicians overview those intriguing advancements to set the degree for additional learn at the lack of orexin/hypocretin neurons in people, rules of sleep and wakefulness by means of the orexin/hypocretin method, and the function of the orexin/hypocretin process in lots of different physiological approaches, together with feeding, autonomic legislation, and neuroendocrine rules. themes of curiosity comprise an overview of the services and the body structure of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and attainable pharmacological remedies. The authors additionally introduce numerous experimental tools for orexin/hypocretin study, and, utilizing multidisciplinary ways, clarify their makes use of and barriers.
Authoritative and cutting-edge, The Orexin/Hypocretin process: body structure and Pathophysiology will reduction scientists within the look for novel bioactive peptides and their receptors, in addition to novel physiological insights and possibilities for the scientific therapy of not just narcolepsy, but in addition a huge variety of ailments linked to endocrine, feeding, and bodyweight regulation.
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Extra info for The Orexin/Hypocretin System: Physiology and Pathophysiology
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The Orexin/Hypocretin System: Physiology and Pathophysiology by Michihiro Mieda PhD, Takeshi Sakurai MD, PhD (auth.), Seiji Nishino MD, PhD, Takeshi Sakurai MD, PhD (eds.)