The Orexin/Hypocretin System: Physiology and Pathophysiology - download pdf or read online

By Michihiro Mieda PhD, Takeshi Sakurai MD, PhD (auth.), Seiji Nishino MD, PhD, Takeshi Sakurai MD, PhD (eds.)

ISBN-10: 1588294447

ISBN-13: 9781588294449

ISBN-10: 1592599508

ISBN-13: 9781592599509

Impairment of orexin/hypocretin signaling reasons narcolepsy-cataplexy in animals and people. so much human narcolepsy-cataplexy circumstances are linked to orexin/hypocretin ligand deficiency, which are detected clinically utilizing cerebrospinal orexin/hypocretin measures and should result in destiny remedies with orexin/hypocretin alternative remedy. within the Orexin/Hypocretin procedure: body structure and Pathophysiology, major researchers and clinicians overview those intriguing advancements to set the degree for additional learn at the lack of orexin/hypocretin neurons in people, rules of sleep and wakefulness by means of the orexin/hypocretin method, and the function of the orexin/hypocretin process in lots of different physiological approaches, together with feeding, autonomic legislation, and neuroendocrine rules. themes of curiosity comprise an overview of the services and the body structure of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and attainable pharmacological remedies. The authors additionally introduce numerous experimental tools for orexin/hypocretin study, and, utilizing multidisciplinary ways, clarify their makes use of and barriers.
Authoritative and cutting-edge, The Orexin/Hypocretin process: body structure and Pathophysiology will reduction scientists within the look for novel bioactive peptides and their receptors, in addition to novel physiological insights and possibilities for the scientific therapy of not just narcolepsy, but in addition a huge variety of ailments linked to endocrine, feeding, and bodyweight regulation.

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Extra info for The Orexin/Hypocretin System: Physiology and Pathophysiology

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324, 169–172. 29. N. (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J. Neurosci. 19, 1072–1087. 30. , and Kuipers, F. (1984) Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat. J. Auton. Nerv. Syst. 11, 59–75. 31. B. (1985) Organization of cerebral cortical afferent systems in the rat. II. Hypothalamocortical projections.

Neurol. 402, 442–459. 15. , and Hokfelt, T. (1998) Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol. 402, 460–474. 16. Pissios, P. and Maratos-Flier, E. (2003) Melanin-concentrating hormone: from fish skin to skinny mammals. Trends Endocrinol. Metab. 14, 243–248. 17. , and Williams, G. (2001) Orexin-A immunoreactive neurons in the rat hypothalamus do not contain neuronal nitric oxide synthase (nNOS).

Et al. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18, 9996–10015. 9. , and Meister, B. (1999) Leptin receptorand STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. J. Neuroendocrinol. 11, 653–663. 10. M. L. Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J. Neurosci. 23, 1487–1497. 40 Marcus and Elmquist 11. G. (2003) Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2.

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The Orexin/Hypocretin System: Physiology and Pathophysiology by Michihiro Mieda PhD, Takeshi Sakurai MD, PhD (auth.), Seiji Nishino MD, PhD, Takeshi Sakurai MD, PhD (eds.)


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