By Peo C. Koller Ph. D., D. Sc. (auth.)
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Extra info for The Role of Chromosomes in Cancer Biology
Table 6 shows the frequency of cells with mitotic aberrations in different regions of the same tumour (KOLLER, 1947 a). Table 6. The frequency of abnormal anaphases (AA) at different regions of a carcinoma Tumour Biopsy sites Carcinoma Cervix A B C D Total 3 Periphery Centre 3 Total no. anaphases Percentage ofAA Total no. 7 51 48 Percentage ofAA Necrotic region Aberrations affecting the structural integrity of chromosomes also occur in malignant cells; the primary event takes place during chromosomal replication at interphase, but the result can only be observed at the following mitosis.
Fig. 18. Histogram showing the chromosome numbers and their frequency induced by imferon (By courtesy of Dr. A. J. S. DAVIES) III a rat sarcoma Imferon, an iron dextran drug used in clinical practice until it was discovered to be carcinogenic, produces sarcomas in rats mainly at the site of injection. The chromosome constitution in one such tumour is shown in Fig. 18. 42 Primary Tumours in Animals The frequency of diploid cells with 42 chromosomes was only five per cent, the majority of cells containing more than this number.
7 a, b, c, d and e). The configuration resembles paired homologous chromosomes (bivalents) of the meiotic division and because of this close similarity FARMER et al. (1903) made the erroneous inference that "carcinogenesis is a process similar to gametogenesis, abnormally occuring in somatic tissue". (2) Non-disjunction of chromosomes is a failure of the two daughter chromosomes to separate at anaphase. They migrate together to the same pole along the spindle, Mitotic Anomalies in Tumours and Boveri's Theory 17 and as a result one daughter nucleus contains more and the other less chromosomes than normal.
The Role of Chromosomes in Cancer Biology by Peo C. Koller Ph. D., D. Sc. (auth.)