By Barry R. Zirkin, Bernard Robaire (auth.), Erwin Goldberg Ph.D. (eds.)
This quantity comprises the lawsuits of the XVth North American Testis Workshop, held in Louisville, Kentucky, April 7 to ten, 1999, to explain present advances in testis biology. the 1st chapters supply an invaluable historic viewpoint of testis body structure and formulate compelling learn questions on very important features of sperm formation and serve as. This prologue units the scene for the rest of the quantity that follows a logical development, because the identify implies, from stem phone to telephone functionality, yet that's unavoidably preceded via intercourse choice, the vital requirement for there being a testis within the first position. this system for this XVth Testis Workshop advanced from recommenda tions of the clinical committee and their recommendation at the number of invited audio system. The XVth Testis Workshop has a powerful comparative style with contributions on worms (Caenorhabditis), flies (Drosophila), and chickens, that are versions that allow and thereby display the facility of genetic analy ses of the molecular mechanisms considering spermatogenesis. A glimpse into the longer term is supplied with info from EST, protein, and genome databases that have already got an impression on development in our figuring out of the male germ mobilephone. even if there's heavy emphasis in those chapters on mobile and molecular e,¥ents, database mining and translational profiling proper to testis functionality and disorder and assisted replica tech nologies are usually not overlooked.
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Additional info for The Testis: From Stem Cell to Sperm Function
5 dpc (23). Biphasic Proliferation of the Coelomic Epithelium Depends on Sry It has long been appreciated that the XY gonad increases in size faster than the XX gonad. A parallel line of investigation in the lab revealed that one mechanism involved in testis organogenesis downstream of Sry is the upregulation of proliferation in the XY gonad. Coelomic epithelial cells undergo biphasic, male-specific proliferation beginning just before the peak of Sry expression (as reported in Ref. 7). Experiments to explore the possibility that proliferation pathways lie downstream of Sry were conducted by injecting a pregnant female with bromodeoxyuridine (BrdU) 2 hours prior to dissection.
Nature 1990;348:450-52. 7. Hacker A, Capel B, Goodfellow P, Lovell-Badge R. Expression of Sry, the mouse sex determining gene. Development 1995;121:1603-14. 8. Jeske YWA, Bowles J, Greenfield A, Koopman P. Expression of a linear Sry transcript in the mouse genital ridge. Nat Gen 1995;10:480-82. 9. Bianchi ME, Falciola L, Ferrari S, Lilley D. The DNA binding site ofHMGl protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins.
Development 1993; 117:273-81. 4 MIS Actions in the Developing Testis MARY MIN-CHIN LEE Introduction Mullerian inhibiting substance (MIS), a gonadal glycoprotein in the TGF-p family of growth and differentiation factors, is recognized primarily for its role in promoting involution of the Mullerian ducts during normal male sexual differentiation. Continued synthesis of MIS by Sertoli cells and expression of its cognate type II receptor in the postnatal testis, however, raised the possibility of additional functions for MIS.
The Testis: From Stem Cell to Sperm Function by Barry R. Zirkin, Bernard Robaire (auth.), Erwin Goldberg Ph.D. (eds.)